Neural alterations of emotion processing in atypical trajectories of psychotic-like experiences
Roxane Assaf, Julien Ouellet, Josiane Bourque, Emmanuel Stip, Marco Leyton, Patricia Conrod and Stéphane Potvin
PMID: 35853901 PMCID: PMC9261083 DOI: 10.1038/s41537-022-00250-y
A unique sample of 86 youths was recruited from a population-based sample of over 3800 adolescents who had been followed from 13 to 17 years of age. Three groups were identified based on validated developmental trajectories: a control trajectory with low and decreasing Psychotic-like experiences (PLEs), and two atypical trajectories with moderate to elevated baseline PLEs that subsequently decreased or increased. All had functional magnetic resonance imaging data collected during a facial emotion processing task. Functional activation and connectivity data were analyzed for different contrasts. The increasing trajectory reported more positive symptoms and exhibited dysconnectivity in areas that influence emotion salience and face perception. Whereas, the decreasing trajectory reported more negative symptoms had impairments in visual information integration areas. These group-specific features might account for the differential symptom expression.
April 21, 2022